There are several potential causes for the sensation of an empty stomach despite not feeling hungry. Some possible explanations include gastrointestinal disorders, medication side effects, and psychological factors.

Gastrointestinal disorders such as gastroparesis or functional dyspepsia can cause the sensation of an empty stomach despite not feeling hungry. Gastroparesis, also known as delayed gastric emptying, is a condition in which the stomach takes longer than normal to empty its contents. This can lead to a feeling of fullness or bloating, even when the person has not eaten much. Functional dyspepsia, also known as non-ulcer dyspepsia, is a functional gastrointestinal disorder characterized by symptoms such as abdominal pain, bloating, and a feeling of fullness despite not eating a large meal.

Medication side effects can also cause the sensation of an empty stomach. Some medications, such as antidepressants and antipsychotics, can interfere with the normal functioning of the digestive system and lead to a feeling of emptiness in the stomach.

Psychological factors, such as stress or anxiety, can also cause the sensation of an empty stomach. Stress and anxiety can affect the functioning of the digestive system and lead to symptoms such as a feeling of emptiness or discomfort in the stomach.

In conclusion, the sensation of an empty stomach despite not feeling hungry can be caused by gastrointestinal disorders, medication side effects, or psychological factors. If the sensation is accompanied by other symptoms or persists despite eating, it is important to consult with a healthcare provider for evaluation and treatment.